Following his transition in 1963-1965 from female to male under the care of Dr. Harry Benjamin, Reed Erickson moved back to Baton Rouge, where, as Rita Alma Erickson, he had previously been a student at LSU. Here he incorporated the Erickson Educational Foundation that would channel his philanthropy to the transgender and gay activist communities.

One of the nation's earliest gay rights groups was founded here. In 1950 at this Cove Avenue residence, Harry Hay, Rudi Gernreich, and two of their friends, Chuck Rowland and Bob Hull, began meeting every week to discuss homosexuality and homosexual disenfranchisement, setting the stage for the modern gay rights movement. The group organized the Mattachine Society. The nearby Mattachine Steps marker was placed in 2012 to honor their efforts.

Dr. Fritz Klein, a leading researcher on bisexualism, community organizer and a creator of the Klein scale (an expansion of the Kinsey scale) and founder of the American Institute of Bisexuality, lived here with his partner, Tom Reise, until his death in 2006 .

The ornate office building was the site of Dr. Harry Benjamin's San Francisco practice, which supported transgender individuals. For many years, Benjamin was seen as the one physician who would help transsexual individuals. His Standards of Care (1979) and 1966 book The Transsexual Phenomenon became the foundation of medical practice and counseling for transgender care. One of Benjamin's earliest transgender cases was that of Reed Erickson who transitioned under Dr. Benjamin's care in 1965.

Founded around 1974 by lesbian feminists in an effort to create their own institutions and organizations, Bloodroot began as a bookstore and restaurant. It's still known for its vegetarian and vegan cuisine, run by two of the original members of the collective, Selma Miriam and Noel Furie.

Hendrie Hall at Yale University housed a variety of LGBTQ organizations in the late 1970s, such as Yalesbians, the New Haven Gay Alliance, the New Haven Gay Coffeehouse, and the New Haven Gay Switchboard.

H Lynn Womack's Guild Press published calendars, gay guides, and books from this building on Barracks Row from 1964 to 1971, in the shadows of the U.S. Capitol Building. Guild Press and Womack became the subject of several obscenity prosecutions that resulted in significant changes to obscenity law and liberalization of censorship law. The Supreme Court's 1962 decision, Manual Enterprises Inc. vs. Day, which Womack brought to the court after being told his magazines were "unmailable," held that homosexual publications were not obscene per se. The Press also briefly published (1970) a national gay newspaper, The Gay Forum.

Critically acclaimed lesbian poet Elizabeth Bishop purchased the house in Key West with her partner Louise Crane. She lived here and in Brazil with subsequent partners Marjorie Stevens and Lota de Macedo.

This club was owned by iconic lesbian club owner Mary Lou "Smokey" Schneider. Opened in 1966, the club presented drag shows with the Smokettes that drew fans from St. Louis on weekends.

Gay Community News, the gay community newspaper of record, published here from 1973 to 1992. The paper's reach in the gay movement was so widespread, members were occasionally referred to as the "GCN Mafia."

Originally known as the East Coast Bisexual Network when it was founded in 1985, The Bisexual Resource Center advocated for bisexual visibility and support. The center grew out of the first national conference of bisexuals.

From 1982 to 1994, Equal Times published on the west side of St. Paul, focusing on political and social issues. Alison Bechdel wrote the Dykes to Watch Out for comic strip for the paper.